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Herbal Products plus Prescription Medications: Potentially Dangerous Combinations
Tips on medications and supplements to avoid taking together
A “natural” product does not mean that it’s safe or effective! Herbal medications are not recommended for children, pregnant or nursing women, the immunosuppressed, or elders on prescription drugs.
Florida Poison Information Center-Tampa 1-800-222-1222

Diet /Herbal Supplement
Medication
Possible Interaction or Side Effect
Aloe Antiarrhythmics, Corticosteroids, Diuretics, Lanoxin May lower potassium leading to excess drug effect and toxicity
Cayenne (Capsicum) Blood-thinners (Aspirin, Coumadin, Plavix, Ticlid) Increased risk of bleeding
Dong Quai Blood-thinners (Aspirin, Coumadin, Plavix, Ticlid) Increased risk of bleeding
Echinacea Immunosuppressants (Cyclosporine) Decrease effectiveness leading to organ rejection
Ephedra (MaHuang) Antihypertensives, Stimulants (Caffeine), Hypoglycemics, Lanoxin, MAOI’s Interfere with drug effect: raising blood pressure or heart rate, elevate blood sugar, cause seizures or strokes
Garlic clove, tablets Blood-thinners (Aspirin, Coumadin, Plavix,Ticlid) Increased risk of bleeding
Garlic clove, tablets Hypoglycemics Increased effect-may lead to severe blood sugar lowering
Garlic clove, tablets HIV medications, Cyclosporine Decrease effectiveness leading to drug resistance or organ rejection
Garlic clove, tablets Oral Contraceptives Decrease effectiveness leading to pregnancy
Ginkgo leaf, Biloba Blood-thinners (as above), Thiazide diuretics Increased risk of bleeding, elevated blood pressure (BP)
Ginkgo leaf, Biloba Seizure lowering drugs,Trazodone (Desyrel) Decrease effectiveness, possible seizures, coma
Ginseng (American, Panax, Siberian) Blood-thinners (as above) Conflicting evidence but may increase risk of bleeding
Ginseng (American, Panax, Siberian) Hypoglycemics Increased effect may lead to extreme blood sugar lowering
Ginseng (American, Panax, Siberian) Immuno suppressants (Cyclosporine) Decrease effectiveness, possible organ rejection 
Ginseng (American, Panax, Siberian) Diuretics (Lasix) Decreased effectiveness leading to elevated BP
Glucosamine Hypoglycemics Increased insulin resistance leading to altered blood sugar
Goldenseal Sedatives May see additive effects intensifying sedation
Hawthorn Cardiovascular Drugs, Digoxin Conflicting evidence but may interfere with effectiveness or increase digoxin effect
Kava-Kava CNS Depressants (Alcohol, Barbiturates, Benzodiazepines-Ativan, Valium, Xanax) May see additive effects intensifying sedation and increased risk of liver damage
St. John’s Wort Crixivan (Indinavir), Cyclosporine, Coumadin, Digoxin, Tegretol, Theophylline Increase metabolism leading to reduced drug effectiveness & potential worsening of disease
St. John’s Wort Antidepressants including: Celexa, Paxil, Prozac, MAOI’s Additive serotonin elevation leading to fever, muscle rigidity, altered mental status
St. John’s Wort Oral Contraceptives Increased metabolism-leading to pregnancy
Valerian CNS Depressants (Alcohol, Barbiturates, Benzodiazepines) Additive effects may intensify sedation
 

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